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Target
Kallikrein-1
Ligand
BDBM50205819
Substrate
n/a
Meas. Tech.
ChEMBL_1628568 (CHEMBL3871153)
Ki
23±n/a nM
Citation
 Richter, JM; Cheney, DL; Bates, JA; Wei, A; Luettgen, JM; Rendina, AR; Harper, TM; Narayanan, R; Wong, PC; Seiffert, D; Wexler, RR; Priestley, ES Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. ACS Med Chem Lett 8:67-72 (2017) [PubMed]  Article 
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM50205819
Synonyms:
CHEMBL3978462
Type:
Small organic molecule
Emp. Form.:
C34H34F3N5O5S
Mol. Mass.:
681.724
SMILES:
C[C@H]1CC(=O)Nc2ccc(c(CN(C)C(=O)[C@H](Nc3ccc4c(N)ncc(F)c4c3)c3ccc(OCC(F)F)c1c3)c2)S(=O)(=O)C1CC1 |r|
Structure:
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