Reaction Details Report a problem with these data
Target
Neurotensin receptor type 2
Ligand
BDBM50206710
Substrate
n/a
Meas. Tech.
ChEMBL_1629221 (CHEMBL3871847)
Ki
12±n/a nM
Citation
 Simeth, NA; Bause, M; Dobmeier, M; Kling, RC; Lachmann, D; Hübner, H; Einsiedel, J; Gmeiner, P; König, B NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids. Bioorg Med Chem 25:350-359 (2017) [PubMed]  Article 
Target
Name:
Neurotensin receptor type 2
Synonyms:
Levocabastine-sensitive neurotensin receptor | NT-R-2 | NTR2 | NTR2 receptor | NTR2_HUMAN | NTSR2 | Neurotensin receptor | Neurotensin receptor 2 | Neurotensin receptor type 2
Type:
PROTEIN
Mol. Mass.:
45404.76
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1281495
Residue:
410
Sequence:
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSAHVVLKARAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAYATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHELETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQVPSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLRAIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNAVSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
  
Inhibitor
Name:
BDBM50206710
Synonyms:
CHEMBL3959801
Type:
Small organic molecule
Emp. Form.:
C40H66N12O9
Mol. Mass.:
859.027
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@@]1(CCO[C@@H]1c1ccc(O)cc1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O |r|
Structure:
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