Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 2
Ligand
BDBM50442988
Substrate
n/a
Meas. Tech.
ChEMBL_1629933 (CHEMBL3872639)
IC50
8200±n/a nM
Citation
 Li, J; Li, Y; Yang, D; Hu, N; Guo, Z; Kuang, C; Yang, Q Establishment of a human indoleamine 2, 3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors. Eur J Med Chem 123:171-179 (2016) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 2
Synonyms:
I23O2_HUMAN | IDO-2 | IDO2 | INDOL1 | Indoleamine 2,3-dioxygenase-like protein 1 | Indoleamine-pyrrole 2,3-dioxygenase-like protein 1
Type:
PROTEIN
Mol. Mass.:
47079.13
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109909
Residue:
420
Sequence:
MLHFHYYDTSNKIMEPHRPNVKTAVPLSLESYHISEEYGFLLPDSLKELPDHYRPWMEIANKLPQLIDAHQLQAHVDKMPLLSCQFLKGHREQRLAHLVLSFLTMGYVWQEGEAQPAEVLPRNLALPFVEVSRNLGLPPILVHSDLVLTNWTKKDPDGFLEIGNLETIISFPGGESLHGFILVTALVEKEAVPGIKALVQATNAILQPNQEALLQALQRLRLSIQDITKTLGQMHDYVDPDIFYAGIRIFLSGWKDNPAMPAGLMYEGVSQEPLKYSGGSAAQSTVLHAFDEFLGIRHSKESGDFLYRMRDYMPPSHKAFIEDIHSAPSLRDYILSSGQDHLLTAYNQCVQALAELRSYHITMVTKYLITAAAKAKHGKPNHLPGPPQALKDRGTGGTAVMSFLKSVRDKTLESILHPRG
  
Inhibitor
Name:
BDBM50442988
Synonyms:
CHEMBL3087009
Type:
Small organic molecule
Emp. Form.:
C15H6F2N2O2
Mol. Mass.:
284.2171
SMILES:
Fc1ccc-2c(c1)C(=O)c1nc3ccc(F)cc3c(=O)n-21
Structure:
Search PDB for entries with ligand similarity: