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TargetD(3) dopamine receptor
LigandBDBM50207112
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1630050
Ki 0.090000±n/a nM
Citation Chen, XWSun, YYFu, LLi, JQ Synthesis and pharmacological characterization of novel N-(trans-4-(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)cyclohexyl)amides as potential multireceptor atypical antipsychotics. Eur J Med Chem123:332-353 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
D(3) dopamine receptor
Name:D(3) dopamine receptor
Synonyms:D2-like dopamine receptor | DOPAMINE D3 | DRD3 | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:n/a
Mol. Mass.:44243.43
Organism:Homo sapiens (Human)
Description:n/a
Residue:400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50207112
NameBDBM50207112
Synonyms:CHEMBL3967779
TypeSmall organic molecule
Emp. Form.C25H31N5OS
Mol. Mass.449.612
SMILESO=C(N[C@H]1CC[C@H](CCN2CCN(CC2)c2nsc3ccccc23)CC1)c1cccnc1 |r,wU:6.6,wD:3.2,(28.69,-24.97,;29.08,-23.48,;28.06,-22.33,;26.55,-22.65,;25.52,-21.51,;24.02,-21.83,;23.54,-23.3,;22.03,-23.62,;21,-22.47,;19.49,-22.79,;19.01,-24.25,;17.51,-24.58,;16.48,-23.43,;16.96,-21.97,;18.46,-21.65,;14.97,-23.75,;14.34,-25.16,;12.82,-25,;12.49,-23.49,;11.16,-22.72,;11.16,-21.18,;12.49,-20.41,;13.83,-21.18,;13.83,-22.72,;24.57,-24.44,;26.07,-24.12,;30.57,-23.08,;30.97,-21.6,;32.46,-21.19,;33.55,-22.28,;33.15,-23.77,;31.66,-24.17,)|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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