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Target
Prostaglandin E synthase
Ligand
BDBM50207305
Substrate
n/a
Meas. Tech.
ChEMBL_1630629 (CHEMBL3873335)
IC50
9700±n/a nM
Citation
 Ramanan, M; Sinha, S; Sudarshan, K; Aidhen, IS; Doble, M Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins. Eur J Med Chem 124:428-434 (2016) [PubMed]  Article 
Target
Name:
Prostaglandin E synthase
Synonyms:
MGST1L1 | MPGES1 | PGES | PIG12 | PTGES | PTGES_HUMAN | Prostaglandin E synthase (PGES-1) | Prostaglandin E synthase 1 (mPGES-1) | Prostaglandin E synthase-1 (PGES-1) | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin E2 synthase-1 ( mPGES-1)
Type:
Protein
Mol. Mass.:
17112.22
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
152
Sequence:
MPAHSLVMSSPALPAFLLCSTLLVIKMYVVAIITGQVRLRKKAFANPEDALRHGGPQYCRSDPDVERCLRAHRNDMETIYPFLFLGFVYSFLGPNPFVAWMHFLVFLVGRVAHTVAYLGKLRAPIRSVTYTLAQLPCASMALQILWEAARHL
  
Inhibitor
Name:
BDBM50207305
Synonyms:
CHEMBL3889873
Type:
Small organic molecule
Emp. Form.:
C16H12O4
Mol. Mass.:
268.2641
SMILES:
COc1ccc(cc1O)-c1cc2ccccc2c(=O)o1
Structure:
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