Reaction Details Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50208154
Substrate
n/a
Meas. Tech.
ChEMBL_1632279 (CHEMBL3874985)
EC50
2500±n/a nM
Citation
 Cox, JM; Chu, HD; Chelliah, MV; Debenham, JS; Eagen, K; Lan, P; Lombardo, M; London, C; Plotkin, MA; Shah, U; Sun, Z; Vaccaro, HM; Venkatraman, S; Suzuki, T; Wang, N; Ashley, ER; Crespo, A; Madeira, M; Leung, DH; Alleyne, C; Ogawa, AM; Souza, S; Thomas-Fowlkes, B; Di Salvo, J; Weinglass, A; Kirkland, M; Pachanski, M; Powles, MA; Tozzo, E; Akiyama, TE; Ujjainwalla, F; Tata, JR; Sinz, CJ Design, Synthesis, and Evaluation of Novel and Selective G-protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists. ACS Med Chem Lett 8:49-54 (2017) [PubMed]  Article 
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50208154
Synonyms:
CHEMBL3973034 | US9708270, 35
Type:
Small organic molecule
Emp. Form.:
C20H23F3N2O3
Mol. Mass.:
396.4034
SMILES:
OC(=O)CC1CCC2(CC1)CCN(CC2)c1cc(OC(F)(F)F)ccc1C#N
Structure:
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