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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50208579
Substrate
n/a
Meas. Tech.
ChEMBL_1632896 (CHEMBL3875688)
IC50
31±n/a nM
Citation
 Gopinath, G; Sankeshi, V; Perugu, S; Alaparthi, MD; Bandaru, S; Pasala, VK; Chittineni, PR; Krupadanam, GLD; Sagurthi, SR Design and synthesis of chiral 2H-chromene-N-imidazolo-amino acid conjugates as aldose reductase inhibitors. Eur J Med Chem 124:750-762 (2016) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50208579
Synonyms:
CHEMBL3883498
Type:
Small organic molecule
Emp. Form.:
C24H22ClN3O3
Mol. Mass.:
435.903
SMILES:
COc1cccc2C=C(COc12)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(Cl)cc1 |r,c:7|
Structure:
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