Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50211601
Substrate
n/a
Meas. Tech.
ChEMBL_1636650 (CHEMBL3879548)
Ki
7.2±n/a nM
Citation
 Altug, C; Günes, H; Nocentini, A; Monti, SM; Buonanno, M; Supuran, CT Synthesis of isoxazole-containing sulfonamides with potent carbonic anhydrase II and VII inhibitory properties. Bioorg Med Chem 25:1456-1464 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50211601
Synonyms:
CHEMBL3889623
Type:
Small organic molecule
Emp. Form.:
C16H13ClN4O4S
Mol. Mass.:
392.817
SMILES:
Nc1onc(c1C(=O)Nc1ccc(cc1)S(N)(=O)=O)-c1ccc(Cl)cc1
Structure:
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