Reaction Details Report a problem with these data
Target
Phosphoglycerate kinase 1
Ligand
BDBM50216700
Substrate
n/a
Meas. Tech.
ChEMBL_371 (CHEMBL825022)
IC50
3600±n/a nM
Citation
 Caplan, NA; Pogson, CI; Hayes, DJ; Blackburn, GM Novel bisphosphonate inhibitors of phosphoglycerate kinase. Bioorg Med Chem Lett 8:515-20 (1998) [PubMed]  Article 
Target
Name:
Phosphoglycerate kinase 1
Synonyms:
Cell migration-inducing gene 10 protein | PGK1 | PGK1_HUMAN | PGKA | PGKA | PRP 2 | Phosphoglycerate kinase 1 | Primer recognition protein 2
Type:
PROTEIN
Mol. Mass.:
44619.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104832
Residue:
417
Sequence:
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI
  
Inhibitor
Name:
BDBM50216700
Synonyms:
CHEMBL149264
Type:
Small organic molecule
Emp. Form.:
C8H8Cl4O6P2
Mol. Mass.:
403.905
SMILES:
OP(O)(=O)C(Cl)(Cl)c1cccc(c1)C(Cl)(Cl)P(O)(O)=O
Structure:
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