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Target
Pancreatic triacylglycerol lipase
Ligand
BDBM24567
Substrate
n/a
Meas. Tech.
ChEMBL_152476 (CHEMBL856675)
IC50
806±n/a nM
Citation
 Dollinger, LM; Howell, AR A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase. Bioorg Med Chem Lett 8:977-8 (1998) [PubMed]  Article 
Target
Name:
Pancreatic triacylglycerol lipase
Synonyms:
LIPP_HUMAN | PL | PNLIP | Pancreatic lipase
Type:
PROTEIN
Mol. Mass.:
51157.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_527250
Residue:
465
Sequence:
MLPLWTLSLLLGAVAGKEVCYERLGCFSDDSPWSGITERPLHILPWSPKDVNTRFLLYTNENPNNFQEVAADSSSISGSNFKTNRKTRFIIHGFIDKGEENWLANVCKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEFLQSAFGYSPSNVHVIGHSLGAHAAGEAGRRTNGTIGRITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDGAPIVPNLGFGMSQVVGHLDFFPNGGVEMPGCKKNILSQIVDIDGIWEGTRDFAACNHLRSYKYYTDSIVNPDGFAGFPCASYNVFTANKCFPCPSGGCPQMGHYADRYPGKTNDVGQKFYLDTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNKGNSKQYEIFKGTLKPDSTHSNEFDSDVDVGDLQMVKFIWYNNVINPTLPRVGASKIIVETNVGKQFNFCSPETVREEVLLTLTPC
  
Inhibitor
Name:
BDBM24567
Synonyms:
(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate | CHEMBL175247 | Orlistat | THLP | Tetrahydrolipstatin | US9328123, Orlistat | Xenical
Type:
Small organic molecule
Emp. Form.:
C29H53NO5
Mol. Mass.:
495.7348
SMILES:
CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O |r|
Structure:
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