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Target
Substance-K receptor
Ligand
BDBM50217512
Substrate
n/a
Meas. Tech.
ChEMBL_142706 (CHEMBL744937)
IC50
19±n/a nM
Citation
 Nishi, T; Fukazawa, T; Ishibashi, K; Nakajima, K; Sugioka, Y; Iio, Y; Kurata, H; Itoh, K; Mukaiyama, O; Satoh, Y; Yamaguchi, T Combined NK1 and NK2 tachykinin receptor antagonists: synthesis and structure-activity relationships of novel oxazolidine analogues. Bioorg Med Chem Lett 9:875-80 (1999) [PubMed]  Article 
Target
Name:
Substance-K receptor
Synonyms:
NK2R_CAVPO | Neurokinin 2 receptor | Neurokinin NK2 | Substance-K receptor | TACR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
45106.00
Organism:
GUINEA PIG
Description:
Neurokinin NK2 TACR2 GUINEA PIG::Q64077
Residue:
402
Sequence:
MGACVIVTNTNISSGLESNTTGITAFSMPTWQLALWATAYLALVLVAVTGNATVTWIILAHQRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVSIYSMTAIAIDRYMAIVHPFQPRLSAPSTKAVIGGIWLVALALAFPQCFYSTITEDEGATKCVVAWPEDSRDKSLLLYHLVVIVLIYLLPLTVMFVAYSIIGLTLWRRAVPRHQAHGANLRHLQAKKKFVKTMVLVVVTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSSTMYNPIIYCCLNRRFRSGFRLAFRCCPWVTPTEEDKLELTHTPSFSLRVNRCHTKEILFMAGDTVPSEATNGQAGGPQDRESVELSSLPGCRAGPSILAKASS
  
Inhibitor
Name:
BDBM50217512
Synonyms:
CHEMBL169132
Type:
Small organic molecule
Emp. Form.:
C33H36F2N2O6S
Mol. Mass.:
626.711
SMILES:
COc1cc(cc(OC)c1OC)C(=O)N1CO[C@@](CCN2CCC3(CC2)[S+]([O-])Cc2ccccc32)(C1)c1ccc(F)c(F)c1
Structure:
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