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Target
D(3) dopamine receptor
Ligand
BDBM50218411
Substrate
n/a
Meas. Tech.
ChEMBL_62585 (CHEMBL673113)
Ki
16±n/a nM
Citation
 Austin, NE; Avenell, KY; Boyfield, I; Branch, CL; Hadley, MS; Jeffrey, P; Johnson, CN; Macdonald, GJ; Nash, DJ; Riley, GJ; Smith, AB; Stemp, G; Thewlis, KM; Vong, AK; Wood, M Novel 2,3,4,5-tetrahydro-1H-3-benzazepines with high affinity and selectivity for the dopamine D3 receptor. Bioorg Med Chem Lett 10:2553-5 (2000) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50218411
Synonyms:
CHEMBL82864
Type:
Small organic molecule
Emp. Form.:
C28H32N4O
Mol. Mass.:
440.5799
SMILES:
O=C(N[C@H]1CC[C@H](CCN2CCc3ccc(cc3CC2)C#N)CC1)c1cc2ccccc2[nH]1 |wU:3.2,wD:6.6,(23.53,-14.18,;23.3,-12.66,;21.86,-12.1,;20.65,-13.05,;20.89,-14.57,;19.7,-15.53,;18.26,-14.97,;17.05,-15.95,;17.29,-17.47,;16.09,-18.45,;14.64,-17.89,;13.31,-18.67,;13.09,-20.2,;11.61,-20.55,;11.16,-22.03,;12.19,-23.11,;13.69,-22.76,;14.13,-21.3,;15.67,-21.19,;16.55,-19.91,;11.72,-24.58,;11.25,-26.05,;18.01,-13.45,;19.23,-12.49,;24.5,-11.69,;25.98,-12.09,;26.83,-10.81,;28.36,-10.58,;28.93,-9.14,;27.96,-7.93,;26.43,-8.17,;25.87,-9.61,;24.43,-10.16,)|
Structure:
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