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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50219813
Substrate
n/a
Meas. Tech.
ChEMBL_157216 (CHEMBL769540)
IC50
460±n/a nM
Citation
 Buckley, GM; Cooper, N; Dyke, HJ; Galleway, FP; Gowers, L; Haughan, AF; Kendall, HJ; Lowe, C; Maxey, R; Montana, JG; Naylor, R; Oxford, J; Peake, JC; Picken, CL; Runcie, KA; Sabin, V; Sharpe, A; Warneck, JB 8-Methoxyquinoline-5-carboxamides as PDE4 inhibitors: a potential treatment for asthma. Bioorg Med Chem Lett 12:1613-5 (2002) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50219813
Synonyms:
CHEMBL296358
Type:
Small organic molecule
Emp. Form.:
C16H11Cl2F3N4O2
Mol. Mass.:
419.185
SMILES:
COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2n(C)c(nc12)C(F)(F)F
Structure:
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