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Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50221001
Substrate
n/a
Meas. Tech.
ChEMBL_157228 (CHEMBL769552)
IC50
3.7±n/a nM
Citation
 Kim, E; Chun, HO; Jung, SH; Kim, JH; Lee, JM; Suh, BC; Xiang, MX; Rhee, CK Improvement of therapeutic index of phosphodiesterase type IV inhibitors as anti-Asthmatics. Bioorg Med Chem Lett 13:2355-8 (2003) [PubMed]  Article 
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
  
Inhibitor
Name:
BDBM50221001
Synonyms:
CHEMBL76257
Type:
Small organic molecule
Emp. Form.:
C21H24N2O3
Mol. Mass.:
352.4269
SMILES:
COc1ccc(cc1OC1CCCC1)C(=N\NC(C)=O)\c1ccccc1
Structure:
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