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Target
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Ligand
BDBM50221033
Substrate
n/a
Meas. Tech.
ChEMBL_212282 (CHEMBL819149)
IC50
49700±n/a nM
Citation
 Li, Z; Francisco, GD; Hu, W; Labthavikul, P; Petersen, PJ; Severin, A; Singh, G; Yang, Y; Rasmussen, BA; Lin, YI; Skotnicki, JS; Mansour, TS 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett 13:2591-4 (2003) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramoylalanine--D-glutamate ligase
Synonyms:
MURD_STAAU | MurD (S. aureus) | murD
Type:
Protein
Mol. Mass.:
49837.61
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurD
Residue:
449
Sequence:
MLNYTGLENKNVLVVGLAKSGYEAAKLLSKLGANVTVNDGKDLSQDAHAKDLESMGISVVSGSHPLTLLDNNPIIVKNPGIPYTVSIIDEAVKRGLKILTEVELSYLISEAPIIAVTGTNGKTTVTSLIGDMFKKSRLTGRLSGNIGYVASKVAQEVKPTDYLVTELSSFQLLGIEKYKPHIAIITNIYSAHLDYHENLENYQNAKKQIYKNQTEEDYLICNYHQRQVIESEELKAKTLYFSTQQEVDGIYIKDGFIVYKGVRIINTEDLVLPGEHNLENILAAVLACILAGVPIKAIIDSLTTFSGIEHRLQYVGTNRTNKYYNDSKATNTLATQFALNSFNQPIIWLCGGLDRGNEFDELIPYMENVRAMVVFGQTKAKFAKLGNSQGKSVIEANNVEDAVDKVQDIIEPNDVVLLSPACASWDQYSTFEERGEKFIERFRAHLPSY
  
Inhibitor
Name:
BDBM50221033
Synonyms:
CHEMBL420601
Type:
Small organic molecule
Emp. Form.:
C12H11N3O2S
Mol. Mass.:
261.3
SMILES:
NC(=O)c1cccc(c1)-n1nc2CCSc2c1O
Structure:
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