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Target
UDP-N-acetylmuramate--L-alanine ligase
Ligand
BDBM50221023
Substrate
n/a
Meas. Tech.
ChEMBL_212278 (CHEMBL816141)
IC50
>102000±n/a nM
Citation
 Li, Z; Francisco, GD; Hu, W; Labthavikul, P; Petersen, PJ; Severin, A; Singh, G; Yang, Y; Rasmussen, BA; Lin, YI; Skotnicki, JS; Mansour, TS 2-Phenyl-5,6-dihydro-2H-thieno[3,2-c]pyrazol-3-ol derivatives as new inhibitors of bacterial cell wall biosynthesis. Bioorg Med Chem Lett 13:2591-4 (2003) [PubMed]  Article 
Target
Name:
UDP-N-acetylmuramate--L-alanine ligase
Synonyms:
MURC_STAAU | MurC (S. aureus) | UDP-N-acetylmuramoyl-L-alanine synthetase | murC
Type:
Protein
Mol. Mass.:
49159.53
Organism:
Staphylococcus aureus (Firmicutes)
Description:
S. aureus MurC
Residue:
437
Sequence:
MTHYHFVGIKGSGMSSLAQIMHDLGHEVQGSDIENYVFTEVALRNKGIKILPFDANNIKEDMVVIQGNAFASSHEEKARAHQMKLDVVSYNDFLGQIIDQYTSVAVTGAHGKTSTTGLLSHVMNGDKKTSFLIGDGTGMGLPESDYFAFEACEYRRHFLSYKPDYAIMTNIDFDHPDYFKDINDVFDAFQEMAHNVKKGIIAWGDDEHLRKIEADVPIYYYGFKDSDDIYAQNIQITDKGTAFDVYVDGEFYDHFLSPQYGDHTVLNALAVIAISYLEKLDVTNIKEALETFGGVKRRFNETTIANQVIVDDYAHHPREISATIETARKKYPHKEVVAVFQPHTFSRTQAFLNEFAESLSKADRVFLCEIFGSIRENTGALTIQDLIDKIEGASLINEDSINVLEQFDNAVVLFKGAGDIQKLQNAYLDKLGMKNAF
  
Inhibitor
Name:
BDBM50221023
Synonyms:
CHEMBL84684
Type:
Small organic molecule
Emp. Form.:
C12H9N3OS
Mol. Mass.:
243.284
SMILES:
Oc1c2SCCc2nn1-c1ccc(cc1)C#N
Structure:
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