Reaction Details Report a problem with these data
Target
Beta-lactamase
Ligand
BDBM50222458
Substrate
n/a
Meas. Tech.
ChEMBL_40551 (CHEMBL652181)
pH
7±n/a
KON
163.000000 M-1s-1
Comments
extracted
Citation
 Page, MI; Hinchliffe, PS; Wood, JM; Harding, LP; Laws, AP Novel mechanism of inhibiting beta-lactamases by sulfonylation using beta-sultams. Bioorg Med Chem Lett 13:4489-92 (2003) [PubMed]  Article 
Target
Name:
Beta-lactamase
Synonyms:
AMPC_ENTCL | ampC
Type:
PROTEIN
Mol. Mass.:
41306.67
Organism:
Enterobacter cloacae
Description:
ChEMBL_40258
Residue:
381
Sequence:
MMRKSLCCALLLGISCSALATPVSEKQLAEVVANTITPLMKAQSVPGMAVAVIYQGKPHYYTFGKADIAANKPVTPQTLFELGSISKTFTGVLGGDAIARGEISLDDAVTRYWPQLTGKQWQGIRMLDLATYTAGGLPLQVPDEVTDNASLLRFYQNWQPQWKPGTTRLYANASIGLFGALAVKPSGMPYEQAMTTRVLKPLKLDHTWINVPKAEEAHYAWGYRDGKAVRVSPGMLDAQAYGVKTNVQDMANWVMANMAPENVADASLKQGIALAQSRYWRIGSMYQGLGWEMLNWPVEANTVVEGSDSKVALAPLPVAEVNPPAPPVKASWVHKTGSTGGFGSYVAFIPEKQIGIVMLANTSYPNPARVEAAYHILEALQ
  
Inhibitor
Name:
BDBM50222458
Synonyms:
CHEMBL341708
Type:
Small organic molecule
Emp. Form.:
C9H9NO3S
Mol. Mass.:
211.238
SMILES:
O=C(N1CCS1(=O)=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: