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TargetProstaglandin G/H synthase (cyclooxygenase)
LigandBDBM50422581
Substrate/Competitorn/a
Meas. Tech.ChEMBL_157825
IC50 947±n/a nM
Citation Hyup, YHKwan, JKKang, SHNoh, MSHa, JYKyu, JKMin, KMHoon, CHChung, S 2,3-Diarylbenzopyran derivatives as a novel class of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett13:413-7 (2003) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase (cyclooxygenase)
Name:Prostaglandin G/H synthase (cyclooxygenase)
Synonyms:Cyclooxygenase-2 | Glucocorticoid-regulated inflammatory cyclooxygenase | Gripghs | Macrophage activation-associated marker protein P71/73 | PES-2 | PGH synthase 2 | PGHS-2 | PHS II | Prostaglandin G/H synthase (cyclooxygenase) | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 | TIS10 protein
Type:Protein
Mol. Mass.:69020.39
Organism:Mus musculus (Mouse)
Description:Q05769
Residue:604
Sequence:
MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
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  Blast E-value cutoff:
BDBM50422581
NameBDBM50422581
Synonyms:CHEMBL336354
TypeSmall organic molecule
Emp. Form.C23H18O4S
Mol. Mass.390.452
SMILESCc1ccccc1-c1c(oc2ccccc2c1=O)-c1ccc(cc1)S(C)(=O)=O |(5.55,1.91,;6.89,1.16,;8.21,1.93,;9.55,1.16,;9.55,-.38,;8.22,-1.15,;6.89,-.38,;5.56,-1.15,;5.56,-2.69,;4.21,-3.46,;2.89,-2.69,;1.56,-3.46,;.22,-2.69,;.22,-1.15,;1.56,-.38,;2.89,-1.15,;4.21,-.38,;4.21,1.16,;6.89,-3.46,;8.22,-2.69,;9.57,-3.46,;9.57,-5,;8.22,-5.77,;6.89,-5,;10.92,-5.79,;12.27,-6.56,;10.13,-7.14,;11.7,-4.43,)|
Structure
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