Target
Dihydrofolate reductase
Ligand
BDBM50405993
Substrate
n/a
Meas. Tech.
ChEMBL_53931 (CHEMBL669353)
pH
7.2±n/a
Ki
1479±n/a nM
Comments
extracted
Citation
 Li, RHansch, CKaufman, BT A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver. J Med Chem 25:435-40 (1982) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM50405993
Synonyms:
CHEMBL19113
Type:
Small organic molecule
Emp. Form.:
C13H15N5O
Mol. Mass.:
257.2911
SMILES:
CC(=O)Nc1ccc(Cc2cnc(N)nc2N)cc1
Structure:
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