Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50405995
Substrate
n/a
Meas. Tech.
ChEMBL_53617 (CHEMBL665572)
pH
7.2±n/a
Ki
53703±n/a nM
Comments
extracted
Citation
 Li, R; Hansch, C; Kaufman, BT A comparison of the inhibitory action of 5-(substituted-benzyl)-2,4-diaminopyrimidines on dihydrofolate reductase from chicken liver with that from bovine liver. J Med Chem 25:435-40 (1982) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
1.5.1.3 | DHFR | DYR_CHICK
Type:
n/a
Mol. Mass.:
21652.69
Organism:
Gallus gallus (Chicken)
Description:
n/a
Residue:
189
Sequence:
VRSLNSIVAVCQNMGIGKDGNLPWPPLRNEYKYFQRMTSTSHVEGKQNAVIMGKKTWFSIPEKNRPLKDRINIVLSRELKEAPKGAHYLSKSLDDALALLDSPELKSKVDMVWIVGGTAVYKAAMEKPINHRLFVTRILHEFESDTFFPEIDYKDFKLLTEYPGVPADIQEEDGIQYKFEVYQKSVLAQ
  
Inhibitor
Name:
BDBM50405995
Synonyms:
CHEMBL31055
Type:
Small organic molecule
Emp. Form.:
C13H15N5O2
Mol. Mass.:
273.2905
SMILES:
NC(=O)COc1cccc(Cc2cnc(N)nc2N)c1
Structure:
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