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TargetS-adenosylmethionine synthetase (MAT 1 and MAT 2)
LigandBDBM50227269
Substrate/Competitorn/a
Meas. Tech.ChEMBL_104797
Ki 670±n/a nM
Citation Vrudhula, VMKappler, FAfshar, CGinell, SLLessinger, LHampton, A Approaches to isozyme-specific inhibitors. 16. A novel methyl-C5' covalent adduct of L-ethionine and beta,gamma-imido-ATP as a potent multisubstrate inhibitor of rat methionine adenosyltransferases. J Med Chem32:885-90 (1989) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Name:S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 104961
Components:This complex has 2 components.
Component 1
Name:S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Synonyms:AdoMet synthetase 1 | MAT 1 | MAT-I/III | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1
Type:PROTEIN
Mol. Mass.:43692.87
Organism:Rattus norvegicus
Description:ChEMBL_104976
Residue:397
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETV
CKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQ
CVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPD
SKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDED
TIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAAR
WVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPG
VIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
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Component 2
Name:S-adenosylmethionine synthetase (MAT 1 and MAT 2)
Synonyms:AdoMet synthetase 2 | MAT 2 | MAT-II | Methionine adenosyltransferase 2 | Methionine adenosyltransferase II | S-adenosylmethionine synthetase gamma form | S-adenosylmethionine synthetase isoform type-2
Type:PROTEIN
Mol. Mass.:43713.68
Organism:Rattus norvegicus
Description:ChEMBL_105118
Residue:395
Sequence:
MNGQLNGFHEAFIEEGTFLFTSESVGEGHPDKICDQINDAVLDAHLQQDPDAKVACETVA
KTGMILLAGEITSRAAIDYQKVVREAIKHIGYDDSSKGFDYKTCNVLVALEQQSPDIAQG
VHLDRNEEDIGAGDQGLMFGYATDETEECMPLTIVLAHKLNAKLAELRRNGTLPWLRPDS
KTQVTVQYMQDRGAVIPIRVHTIVISVQHDEEVCLDEMRDALKEKLIKAVVPAKYLDEDT
IYHLQPSGRFVIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARW
VAKSLVKGGLCRRVLVQVSYAIGVSHPLSISIFHYGTSQKSERELLEIVKNNFDLRPGVI
VRDLDLKKPIYQRTAAYGHFGRDSFPWEVPKKLKY
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BDBM50227269
NameBDBM50227269
Synonyms:CHEMBL3706402
TypeSmall organic molecule
Emp. Form.C15H26N7O14P3S
Mol. Mass.653.392
SMILES[H][C@@]1(O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)[C@H](CSCCC(N)C(O)=O)OP(O)(=O)OP(O)(=O)NP(O)(O)=O |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a