Reaction Details Report a problem with these data
Target
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Ligand
BDBM50228834
Substrate
n/a
Meas. Tech.
ChEMBL_40449 (CHEMBL652387)
IC50
81±n/a nM
Citation
Saccomano, NA; Vinick, FJ; Koe, BK; Nielsen, JA; Whalen, WM; Meltz, M; Phillips, D; Thadieo, PF; Jung, S; Chapin, DS Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(bicycloalkyloxy)-4-methoxyphenyl]-2-imidazolidinones. J Med Chem 34:291-8 (1991) [PubMed] Article
More Info.:
Target
Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Synonyms:
Dpde1 | PDE4C_RAT | Pde4c
Type:
PROTEIN
Mol. Mass.:
60038.21
Organism:
Rattus norvegicus
Description:
ChEMBL_104732
Residue:
536
Sequence:
NSSRTSSAASDLHGEDMIVTPFAQVLASLRTVRSNVAALAHGAGSATRQALLGTPPQSSQQAAPAEESGLQLAQETLEELDWCLEQLETLQTRRSVGEMASNKFKRMLNRELTHLSETSRSGNQVSEYISQTFLDQQAEVELPAPPTEDHPWPMAQITGLRKSCHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAVIFRVLQERDLLKTFQIPADTLLRYLLTLEGHYHSNVAYHNSIHAADVVQSAHVLLGTPALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQGENCDIFQNLSTKQKLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGFIDYIAHPLWETWADLVHPDAQELLDTLEDNREWYQSRVPCSPPHAIGPDRFKFELTLEETEEEEEEDERH
Inhibitor
Name:
BDBM50228834
Synonyms:
CHEMBL101172
Type:
Small organic molecule
Emp. Form.:
C19H26N2O3
Mol. Mass.:
330.4213
SMILES:
COc1ccc(cc1OC1CC2CCC1CC2)C1CNC(=O)N1C |TLB:8:9:13.12:15.16,(16.59,-.52,;15.25,-1.29,;15.25,-2.83,;16.6,-3.6,;16.6,-5.14,;15.25,-5.91,;13.93,-5.14,;13.93,-3.6,;12.59,-2.83,;12.59,-1.29,;12.64,.1,;10.82,.02,;9.82,-1.55,;9.83,-2.99,;10.73,-1.36,;9.99,-.2,;10.23,.93,;15.25,-7.45,;14.03,-8.37,;14.5,-9.83,;16.04,-9.83,;16.95,-11.08,;16.52,-8.37,;17.98,-7.89,)|