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Reaction Details
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TargetAngiotensin II receptor
LigandBDBM50229507
Substrate/Competitorn/a
Meas. Tech.ChEMBL_36467
IC50 120000±n/a nM
Citation Bovy, PRCollins, JTOlins, GMMcMahon, EGHutton, WC Conformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties. J Med Chem34:2410-4 (1991) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Angiotensin II receptor
Name:Angiotensin II receptor
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 36477
Components:This complex has 3 components.
Component 1
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:AT1B | AT3 | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | Type-1B angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40929.44
Organism:RAT
Description:Angiotensin II AT1B 0 RAT::P29089
Residue:359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVC
AFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
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Component 2
Name:Angiotensin II receptor
Synonyms:AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Type-2 angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:41346.62
Organism:RAT
Description:Angiotensin II AT2 0 0::P35351
Residue:363
Sequence:
MKDNFSFAATSRNITSSLPFDNLNATGTNESAFNCSHKPADKHLEAIPVLYYMIFVIGFA
VNIVVVSLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYVVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALTWMGIINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRETMSCRKSSSLREMDT
FVS
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Component 3
Name:Angiotensin II receptor (AT-1) type-1
Synonyms:ANGIOTENSIN AT1 | Angiotensin II AT1 | Angiotensin II AT1A | Angiotensin II receptor (AT-1) type-1 | Type-1A angiotensin II receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:40910.53
Organism:RAT
Description:ANGIOTENSIN AT1 AGTR1 RAT::P25095
Residue:359
Sequence:
MALNSSAEDGIKRIQDDCPKAGRHSYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLK
TVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLT
CLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIHRNVYFIENTNITVC
AFHYESRNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFR
IIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCKISDIVDTAMPITICIAYFNNCLNPL
FYGFLGKKFKKYFLQLLKYIPPKAKSHSSLSTKMSTLSYRPSDNMSSSAKKPASCFEVE
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BDBM50229507
NameBDBM50229507
Synonyms:CHEMBL311702
TypeSmall organic molecule
Emp. Form.C24H27ClN2O5
Mol. Mass.458.935
SMILESCCCCc1nc(Cl)c(CO)n1Cc1cc(OC)c(c(OC)c1)-c1ccccc1C(O)=O |(1.34,-22.87,;2.39,-21.73,;1.91,-20.26,;2.95,-19.12,;2.48,-17.66,;1.01,-17.18,;1.03,-15.64,;-.21,-14.72,;2.5,-15.17,;2.97,-13.7,;4.49,-13.39,;3.39,-16.41,;4.93,-16.43,;5.7,-17.76,;7.23,-17.76,;7.99,-19.09,;9.53,-19.09,;10.31,-17.76,;7.22,-20.42,;5.68,-20.42,;4.9,-21.75,;3.36,-21.75,;4.91,-19.09,;7.99,-21.77,;7.21,-23.08,;7.96,-24.43,;9.5,-24.44,;10.29,-23.1,;9.52,-21.77,;10.83,-20.98,;12.02,-21.99,;11.11,-19.47,)|
Structure
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