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TargetThymidine kinase
LigandBDBM50229858
Substrate/Competitorn/a
Meas. Tech.ChEMBL_208025
IC50 30200±n/a nM
Citation Gambino, JFocher, FHildebrand, CMaga, GNoonan, TSpadari, SWright, G Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases. J Med Chem35:2979-83 (1992) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thymidine kinase
Name:Thymidine kinase
Synonyms:TK | Thymidine kinase | UL23
Type:PROTEIN
Mol. Mass.:40883.42
Organism:Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)
Description:ChEMBL_213
Residue:376
Sequence:
MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPT
ICDLARTFAREMGEAN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50229858
NameBDBM50229858
Synonyms:CHEMBL101730
TypeSmall organic molecule
Emp. Form.C12H12N6O
Mol. Mass.256.2633
SMILESNCc1cccc(Nc2nc(O)c3[nH]cnc3n2)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
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