Reaction Details Report a problem with these data
Target
C5a anaphylatoxin chemotactic receptor 1
Ligand
BDBM50229893
Substrate
n/a
Meas. Tech.
ChEBML_41451
IC50
>146000±n/a nM
Citation
 Lanza, TJ; Durette, PL; Rollins, T; Siciliano, S; Cianciarulo, DN; Kobayashi, SV; Caldwell, CG; Springer, MS; Hagmann, WK Substituted 4,6-diaminoquinolines as inhibitors of C5a receptor binding. J Med Chem 35:252-8 (1992) [PubMed]  Article 
Target
Name:
C5a anaphylatoxin chemotactic receptor 1
Synonyms:
C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:
Enzyme
Mol. Mass.:
39347.68
Organism:
Homo sapiens (Human)
Description:
P21730
Residue:
350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVWVTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNMYASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREEYFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKTLKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIYVVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
  
Inhibitor
Name:
BDBM50229893
Synonyms:
CHEMBL315307
Type:
Small organic molecule
Emp. Form.:
C21H18N4O
Mol. Mass.:
342.3938
SMILES:
Cc1ccc2cc(NC(=O)Nc3ccc4nc(C)ccc4c3)ccc2n1
Structure:
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