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Target
Carbonic anhydrase 12
Ligand
BDBM50226745
Substrate
n/a
Meas. Tech.
ChEMBL_1643900 (CHEMBL3992829)
Ki
>50000±n/a nM
Citation
 van Kuijk, SJA; Parvathaneni, NK; Niemans, R; van Gisbergen, MW; Carta, F; Vullo, D; Pastorekova, S; Yaromina, A; Supuran, CT; Dubois, LJ; Winum, JY; Lambin, P New approach of delivering cytotoxic drugs towards CAIX expressing cells: A concept of dual-target drugs. Eur J Med Chem 127:691-702 (2017) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 12
Synonyms:
CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:
Enzyme
Mol. Mass.:
39456.00
Organism:
Homo sapiens (Human)
Description:
Catalytic domain of human cloned isozyme was used in the assay
Residue:
354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHLHWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
  
Inhibitor
Name:
BDBM50226745
Synonyms:
CHEMBL4073065
Type:
Small organic molecule
Emp. Form.:
C18H17N5O5S2
Mol. Mass.:
447.488
SMILES:
CS(=O)(=O)c1ccc(cc1)-c1cnc(NS(N)(=O)=O)c(n1)C(=O)Nc1ccccc1
Structure:
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