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Target
Glycine receptor subunit alpha-3
Ligand
BDBM50229711
Substrate
n/a
Meas. Tech.
ChEBML_1644301
EC50
450±n/a nM
Citation
 Bregman, H; Simard, JR; Andrews, KL; Ayube, S; Chen, H; Gunaydin, H; Guzman-Perez, A; Hu, J; Huang, L; Huang, X; Krolikowski, PH; Lehto, SG; Lewis, RT; Michelsen, K; Pegman, P; Plant, MH; Shaffer, PL; Teffera, Y; Yi, S; Zhang, M; Gingras, J; DiMauro, EF The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem 60:1105-1125 (2017) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-3
Synonyms:
GLRA3 | GLRA3_HUMAN | Glycine receptor alpha-3/beta
Type:
PROTEIN
Mol. Mass.:
53809.29
Organism:
Homo sapiens (Human)
Description:
ChEMBL_967474
Residue:
464
Sequence:
MAHVRHFRTLVSGFYFWEAALLLSLVATKETDSARSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQDEAPVQVAEGLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSDMDDEVRESRFSFTAYGMGPCLQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIYKILRHEDIHQQQD
  
Inhibitor
Name:
BDBM50229711
Synonyms:
CHEMBL4074873
Type:
Small organic molecule
Emp. Form.:
C19H17N3O4S
Mol. Mass.:
383.421
SMILES:
[H][C@@]12CN(C[C@]1([H])c1cnccc1N(C)C2=O)S(=O)(=O)c1ccc2occc2c1 |r|
Structure:
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