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TargetPeptidyl-prolyl cis-trans isomerase A
LigandBDBM50230294
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1644715
Ki 4.0±n/a nM
Citation Steadman, VAPettit, SBPoullennec, KGLazarides, LKeats, AJDean, DKStanway, SJAustin, CASanvoisin, JAWatt, GMFliri, HGLiclican, ACJin, DWong, MHLeavitt, SALee, YJTian, YFrey, CRAppleby, TCSchmitz, UJansa, PMackman, RLSchultz, BE Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A. J Med Chem60:1000-1017 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Peptidyl-prolyl cis-trans isomerase A
Name:Peptidyl-prolyl cis-trans isomerase A
Synonyms:CYPA | CYPA PPIase | Cyclophilin A | Cyclosporin A-binding protein | PPIA | PPIase A | Rotamase A
Type:Protein
Mol. Mass.:18015.32
Organism:Homo sapiens (Human)
Description:P62937
Residue:165
Sequence:
MVNPTVFFDIAVDGEPLGRVSFELFADKVPKTAENFRALSTGEKGFGYKGSCFHRIIPGF
MCQGGDFTRHNGTGGKSIYGEKFEDENFILKHTGPGILSMANAGPNTNGSQFFICTAKTE
WLDGKHVVFGKVKEGMNIVEAMERFGSRNGKTSKKITIADCGQLE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50230294
NameBDBM50230294
Synonyms:CHEMBL4071740
TypeSmall organic molecule
Emp. Form.C36H48N4O7
Mol. Mass.648.7889
SMILESCO[C@@H]1CC\C=C\c2cccc(c2)[C@@H](C)OC(=O)[C@@H]2CCCN(N2)C(=O)[C@H](Cc2cccc(O)c2)NC(=O)[C@@H](NC(=O)[C@@H]1C)C(C)C |r,t:5|
Structure
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n/a