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Target
Polycomb protein EED
Ligand
BDBM50231877
Substrate
n/a
Meas. Tech.
ChEMBL_1645614 (CHEMBL3994543)
IC50
30±n/a nM
Citation
 Baranczak, A; Tu, NP; Marjanovic, J; Searle, PA; Vasudevan, A; Djuric, SW Integrated Platform for Expedited Synthesis-Purification-Testing of Small Molecule Libraries. ACS Med Chem Lett 8:461-465 (2017) [PubMed]  Article 
Target
Name:
Polycomb protein EED
Synonyms:
EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED
Type:
Protein
Mol. Mass.:
50201.68
Organism:
Homo sapiens (Human)
Description:
O75530
Residue:
441
Sequence:
MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTPNAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRLR
  
Inhibitor
Name:
BDBM50231877
Synonyms:
CHEMBL4064647
Type:
Small organic molecule
Emp. Form.:
C26H35FN4O2
Mol. Mass.:
454.5801
SMILES:
COC(=O)N1CCN(CC1)c1ccc(cc1)[C@H]1CN(Cc2c(C)cccc2F)C[C@@H]1N(C)C |r|
Structure:
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