Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50232178
Substrate
n/a
Meas. Tech.
ChEBML_1646196
Ki
1.7±n/a nM
Citation
 Cherukupalli, S; Karpoormath, R; Chandrasekaran, B; Hampannavar, GA; Thapliyal, N; Palakollu, VN An insight on synthetic and medicinal aspects of pyrazolo[1,5-a]pyrimidine scaffold. Eur J Med Chem 126:298-352 (2017) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50232178
Synonyms:
CHEMBL4081285
Type:
Small organic molecule
Emp. Form.:
C20H25ClN4
Mol. Mass.:
356.892
SMILES:
CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(Cl)cc1C |(28.23,-5.21,;26.9,-5.98,;26.9,-7.52,;28.23,-8.29,;29.57,-7.52,;25.56,-8.29,;25.56,-9.83,;24.24,-10.61,;24.24,-12.15,;22.9,-12.92,;25.56,-12.91,;26.89,-12.15,;28.36,-12.63,;29.27,-11.38,;30.81,-11.38,;28.36,-10.13,;26.89,-10.61,;28.84,-14.09,;27.8,-15.23,;28.28,-16.69,;29.78,-17.01,;30.26,-18.48,;30.82,-15.86,;30.34,-14.4,;31.36,-13.25,)|
Structure:
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