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Target
Procathepsin L
Ligand
BDBM50330030
Substrate
n/a
Meas. Tech.
ChEMBL_1647855 (CHEMBL3996911)
Ki
3.7±n/a nM
Citation
 Parker, EN; Odutola, SO; Wang, Y; Strecker, TE; Mukherjee, R; Shi, Z; Chaplin, DJ; Trawick, ML; Pinney, KG Synthesis and biological evaluation of a water-soluble phosphate prodrug salt and structural analogues of KGP94, a lead inhibitor of cathepsin L. Bioorg Med Chem Lett 27:1304-1310 (2017) [PubMed]  Article 
Target
Name:
Procathepsin L
Synonyms:
CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:
Enzyme
Mol. Mass.:
37557.19
Organism:
Homo sapiens (Human)
Description:
Purchased from Calbiochem (San Diego, CA).
Residue:
333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDWREKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
  
Inhibitor
Name:
BDBM50330030
Synonyms:
CHEMBL1269632 | [(3-Bromophenyl)-(3-hydroxyphenyl)-ketone]thiosemicarbazone
Type:
Small organic molecule
Emp. Form.:
C14H12BrN3OS
Mol. Mass.:
350.234
SMILES:
NC(=S)NN=C(c1cccc(O)c1)c1cccc(Br)c1 |w:4.3|
Structure:
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