Reaction Details Report a problem with these data
Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50233427
Substrate
n/a
Meas. Tech.
ChEMBL_1650851 (CHEMBL3999985)
IC50
100±n/a nM
Citation
 Yue, EW; Sparks, R; Polam, P; Modi, D; Douty, B; Wayland, B; Glass, B; Takvorian, A; Glenn, J; Zhu, W; Bower, M; Liu, X; Leffet, L; Wang, Q; Bowman, KJ; Hansbury, MJ; Wei, M; Li, Y; Wynn, R; Burn, TC; Koblish, HK; Fridman, JS; Emm, T; Scherle, PA; Metcalf, B; Combs, AP INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett 8:486-491 (2017) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50233427
Synonyms:
CHEMBL4091895
Type:
Small organic molecule
Emp. Form.:
C12H13BrFN5O3
Mol. Mass.:
374.166
SMILES:
COCCNc1nonc1\C(Nc1ccc(F)c(Br)c1)=N\O
Structure:
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