Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50300305
Substrate
n/a
Meas. Tech.
ChEMBL_1650851 (CHEMBL3999985)
IC50
19±n/a nM
Citation
 Yue, EWSparks, RPolam, PModi, DDouty, BWayland, BGlass, BTakvorian, AGlenn, JZhu, WBower, MLiu, XLeffet, LWang, QBowman, KJHansbury, MJWei, MLi, YWynn, RBurn, TCKoblish, HKFridman, JSEmm, TScherle, PAMetcalf, BCombs, AP INCB24360 (Epacadostat), a Highly Potent and Selective Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitor for Immuno-oncology. ACS Med Chem Lett 8:486-491 (2017) [PubMed]  Article 
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_HUMAN | IDO | IDO-1 | IDO1 | INDO | Indoleamine 2,3-Dioxygenasae (IDO) | Indoleamine 2,3-dioxygenase | Indoleamine-pyrrole 2,3-dioxygenase
Type:
Enzyme
Mol. Mass.:
45330.80
Organism:
Homo sapiens (Human)
Description:
P14902
Residue:
403
Sequence:
MAHAMENSWTISKEYHIDEEVGFALPNPQENLPDFYNDWMFIAKHLPDLIESGQLRERVEKLNMLSIDHLTDHKSQRLARLVLGCITMAYVWGKGHGDVRKVLPRNIAVPYCQLSKKLELPPILVYADCVLANWKKKDPNKPLTYENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIPTVFKAMQMQERDTLLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRIYLSGWKGNPQLSDGLVYEGFWEDPKEFAGGSAGQSSVFQCFDVLLGIQQTAGGGHAAQFLQDMRRYMPPAHRNFLCSLESNPSVREFVLSKGDAGLREAYDACVKALVSLRSYHLQIVTKYILIPASQQPKENKTSEDPSKLEAKGTGGTDLMNFLKTVRSTTEKSLLKEG
  
Inhibitor
Name:
BDBM50300305
Synonyms:
4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide | CHEMBL584991 | US10669273, Compound INCB024360
Type:
Small organic molecule
Emp. Form.:
C9H7ClFN5O2
Mol. Mass.:
271.636
SMILES:
Nc1nonc1C(NO)=Nc1ccc(F)c(Cl)c1 |w:9.10|
Structure:
Search PDB for entries with ligand similarity: