Target
Tryptophan 5-hydroxylase 1
Ligand
BDBM50234205
Substrate
n/a
Meas. Tech.
ChEMBL_1652543 (CHEMBL4001798)
IC50
25±n/a nM
Citation
 Goldberg, DRDe Lombaert, SAiello, RBourassa, PBarucci, NZhang, QParalkar, VStein, AJHolt, MValentine, JZavadoski, W Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg Med Chem Lett 27:413-419 (2017) [PubMed]  Article 
Target
Name:
Tryptophan 5-hydroxylase 1
Synonyms:
TPH | TPH1 | TPH1_HUMAN | TPRH | TRPH | Tryptophan 5-monooxygenase 1
Type:
PROTEIN
Mol. Mass.:
50990.64
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1361824
Residue:
444
Sequence:
MIEDNKENKDHSLERGRASLIFSLKNEVGGLIKALKIFQEKHVNLLHIESRKSKRRNSEFEIFVDCDINREQLNDIFHLLKSHTNVLSVNLPDNFTLKEDGMETVPWFPKKISDLDHCANRVLMYGSELDADHPGFKDNVYRKRRKYFADLAMNYKHGDPIPKVEFTEEEIKTWGTVFQELNKLYPTHACREYLKNLPLLSKYCGYREDNIPQLEDVSNFLKERTGFSIRPVAGYLSPRDFLSGLAFRVFHCTQYVRHSSDPFYTPEPDTCHELLGHVPLLAEPSFAQFSQEIGLASLGASEEAVQKLATCYFFTVEFGLCKQDGQLRVFGAGLLSSISELKHALSGHAKVKPFDPKITCKQECLITTFQDVYFVSESFEDAKEKMREFTKTIKRPFGVKYNPYTRSIQILKDTKSITSAMNELQHDLDVVSDALAKVSRKPSI
  
Inhibitor
Name:
BDBM50234205
Synonyms:
CHEMBL4088856
Type:
Small organic molecule
Emp. Form.:
C30H29F3N6O3
Mol. Mass.:
578.5849
SMILES:
Nc1nc(O[C@H](c2ccc(cc2)-c2ccc3cnccc3c2)C(F)(F)F)cc(n1)N1CCC2(CN[C@@H](C2)C(O)=O)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: