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Target
Dual specificity protein kinase CLK1
Ligand
BDBM50234810
Substrate
n/a
Meas. Tech.
ChEMBL_1653990 (CHEMBL4003356)
IC50
40±n/a nM
Citation
 Murár, M; Dobia?, J; ?ramel, P; Addová, G; Hanquet, G; Bohác, A Novel CLK1 inhibitors based on N-aryloxazol-2-amine skeleton - A possible way to dual VEGFR2 TK/CLK ligands. Eur J Med Chem 126:754-761 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK1
Synonyms:
CDC-like kinase 1 | CDC-like kinase 1 (CLK1) | CDC2-like kinase 1 (CLK1) | CLK | CLK1 | CLK1_HUMAN | Dual specificity protein kinase CLK1 | Dual specificity protein kinase CLK1/CLK4 | Dual specificty protein kinase CLK1
Type:
Protein
Mol. Mass.:
57322.21
Organism:
Homo sapiens (Human)
Description:
P49759
Residue:
484
Sequence:
MRHSKRTYCPDWDDKDWDYGKWRSSSSHKRRKRSHSSAQENKRCKYNHSKMCDSHYLESRSINEKDYHSRRYIDEYRNDYTQGCEPGHRQRDHESRYQNHSSKSSGRSGRSSYKSKHRIHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYEIVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQMLEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPENILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRKRKYFHHDRLDWDEHSSAGRYVSRRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFFDLLKKSI
  
Inhibitor
Name:
BDBM50234810
Synonyms:
CHEMBL4065167
Type:
Small organic molecule
Emp. Form.:
C20H20N2O4S
Mol. Mass.:
384.449
SMILES:
CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(\C=C\c3ccccc3)o2)c1
Structure:
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