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Target
Proteasome subunit beta type-5
Ligand
BDBM50234982
Substrate
n/a
Meas. Tech.
ChEMBL_1654306 (CHEMBL4003672)
IC50
0.900000±n/a nM
Citation
 Zhuang, R; Gao, L; Lv, X; Xi, J; Sheng, L; Zhao, Y; He, R; Hu, X; Shao, Y; Pan, X; Liu, S; Huang, W; Zhou, Y; Li, J; Zhang, J Exploration of novel piperazine or piperidine constructed non-covalent peptidyl derivatives as proteasome inhibitors. Eur J Med Chem 126:1056-1070 (2017) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-5
Synonyms:
20S proteasome chymotrypsin-like | 26S proteosome | LMPX | MB1 | PSB5_HUMAN | PSMB5 | Proteasome Macropain subunit MB1 | Proteasome subunit beta type-1/beta type-5 | X
Type:
Protein
Mol. Mass.:
28480.96
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
263
Sequence:
MALASVLERPLPVNQRGFFGLGGRADLLDLGPGSLSDGLSLAAPGWGVPEEPGIEMLHGTTTLAFKFRHGVIVAADSRATAGAYIASQTVKKVIEINPYLLGTMAGGAADCSFWERLLARQCRIYELRNKERISVAAASKLLANMVYQYKGMGLSMGTMICGWDKRGPGLYYVDSEGNRISGATFSVGSGSVYAYGVMDRGYSYDLEVEQAYDLARRAIYQATYRDAYSGGAVNLYHVREDGWIRVSSDNVADLHEKYSGSTP
  
Inhibitor
Name:
BDBM50234982
Synonyms:
CHEMBL4102324
Type:
Small organic molecule
Emp. Form.:
C36H46ClN7O5S
Mol. Mass.:
724.312
SMILES:
CC(C)(C)CNC(=O)C[C@H](NC(=O)N1CCC(CC1)C(=O)Nc1nccs1)C(=O)N[C@@H](CCc1ccccc1)C(=O)NCc1ccccc1Cl |r|
Structure:
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