| Reaction Details |
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 | Report a problem with these data |
| Target | SRSF protein kinase 1 |
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| Ligand | BDBM50235034 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1654400 |
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| Ki | 890±n/a nM |
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| Citation |  Shi, Y; Park, J; Lagisetti, C; Zhou, W; Sambucetti, LC; Webb, TR A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett27:406-412 (2017) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| SRSF protein kinase 1 |
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| Name: | SRSF protein kinase 1 |
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| Synonyms: | 2.7.11.1 | SFRS protein kinase 1 | SR-protein-specific kinase 1 | SRSF protein kinase 1 | Serine/arginine-rich protein-specific kinase 1 | Srpk1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 73082.57 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_117355 |
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| Residue: | 648 |
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| Sequence: | MERKVLALQARKKRTKAKKDKAQRKPETQHRGSAPHSESDIPEQEEEILGSDDDEQEDPN
DYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTET
ALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSN
YQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQR
SGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQ
KRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVI
GVVNYPENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPTASE
TMVCQSSAEQSLTRQDITQLEESIRADTPSGDEQEPNGALDSKGKFSAGNFLINPLEPKN
AEKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATG
DYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWG
LLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWLNS
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| BDBM50235034 |
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| Name | BDBM50235034 |
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| Synonyms: | CHEMBL4064277 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F3N3O |
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| Mol. Mass. | 349.3502 |
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| SMILES | FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1 |
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| Structure | 
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| n/a |
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