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Target
SRSF protein kinase 1
Ligand
BDBM50235034
Substrate
n/a
Meas. Tech.
ChEMBL_1654400 (CHEMBL4003766)
Ki
890±n/a nM
Citation
 Shi, Y; Park, J; Lagisetti, C; Zhou, W; Sambucetti, LC; Webb, TR A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett 27:406-412 (2017) [PubMed]  Article 
Target
Name:
SRSF protein kinase 1
Synonyms:
2.7.11.1 | SFRS protein kinase 1 | SR-protein-specific kinase 1 | SRPK1_MOUSE | SRSF protein kinase 1 | Serine/arginine-rich protein-specific kinase 1 | Srpk1
Type:
PROTEIN
Mol. Mass.:
73082.57
Organism:
Mus musculus
Description:
ChEMBL_117355
Residue:
648
Sequence:
MERKVLALQARKKRTKAKKDKAQRKPETQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVDRPLTENPPNKMTQEKLEESNSIGQDQTLTERGGEGGAPEINCNGVIGVVNYPENSNNETLRHKEDLHNANDCDVHTLKQEPSFLNSSNGDSSPSQDTDSCTPTASETMVCQSSAEQSLTRQDITQLEESIRADTPSGDEQEPNGALDSKGKFSAGNFLINPLEPKNAEKLQVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM50235034
Synonyms:
CHEMBL4064277
Type:
Small organic molecule
Emp. Form.:
C18H18F3N3O
Mol. Mass.:
349.3502
SMILES:
FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1
Structure:
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