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Target
Dual specificity protein kinase CLK3
Ligand
BDBM50235028
Substrate
n/a
Meas. Tech.
ChEMBL_1654404 (CHEMBL4003770)
IC50
>1000±n/a nM
Citation
 Shi, Y; Park, J; Lagisetti, C; Zhou, W; Sambucetti, LC; Webb, TR A triple exon-skipping luciferase reporter assay identifies a new CLK inhibitor pharmacophore. Bioorg Med Chem Lett 27:406-412 (2017) [PubMed]  Article 
Target
Name:
Dual specificity protein kinase CLK3
Synonyms:
CDC2-like kinase 3 (CLK3) | CLK3 | CLK3_HUMAN | Dual specificity protein kinase CLK3
Type:
Protein
Mol. Mass.:
73570.11
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
638
Sequence:
MPVLSARRRELADHAGSGRRSGPSPTARSGPHLSALRAQPARAAHLSGRGTYVRRDTAGGGPGQARPLGPPGTSLLGRGARRSGEGWCPGAFESGARAARPPSRVEPRLATAASREGAGLPRAEVAAGSGRGARSGEWGLAAAGAWETMHHCKRYRSPEPDPYLSYRWKRRRSYSREHEGRLRYPSRREPPPRRSRSRSHDRLPYQRRYRERRDSDTYRCEERSPSFGEDYYGPSRSRHRRRSRERGPYRTRKHAHHCHKRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGEGTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENILFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGRYVKENCKPLKSYMLQDSLEHVQLFDLMRRMLEFDPAQRITLAEALLHPFFAGLTPEERSFHTSRNPSR
  
Inhibitor
Name:
BDBM50235028
Synonyms:
CHEMBL1532768
Type:
Small organic molecule
Emp. Form.:
C19H24ClN7
Mol. Mass.:
385.894
SMILES:
CCn1cnc2c(Nc3cccc(Cl)c3)nc(N[C@@H]3CCCC[C@H]3N)nc12
Structure:
Search PDB for entries with ligand similarity: