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Target
Perforin-1
Ligand
BDBM50235178
Substrate
n/a
Meas. Tech.
ChEMBL_1654903 (CHEMBL4004269)
IC50
>20000±n/a nM
Citation
 Spicer, JA; Miller, CK; O'Connor, PD; Jose, J; Huttunen, KM; Jaiswal, JK; Denny, WA; Akhlaghi, H; Browne, KA; Trapani, JA Benzenesulphonamide inhibitors of the cytolytic protein perforin. Bioorg Med Chem Lett 27:1050-1054 (2017) [PubMed]  Article 
Target
Name:
Perforin-1
Synonyms:
PERF_HUMAN | PFP | PRF1
Type:
PROTEIN
Mol. Mass.:
61392.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1285138
Residue:
555
Sequence:
MAARLLLLGILLLLLPLPVPAPCHTAARSECKRSHKFVPGAWLAGEGVDVTSLRRSGSFPVDTQRFLRPDGTCTLCENALQEGTLQRLPLALTNWRAQGSGCQRHVTRAKVSSTEAVARDAARSIRNDWKVGLDVTPKPTSNVHVSVAGSHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPDFKRALGDLPHHFNASTQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIGIHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGIQAGPEQYSAWVNSLPGSPGLVDYTLEPLHVLLDSQDPRREALRRALSQYLTDRARWRDCSRPCPPGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAYVKLFFGGQELRTSTVWDNNNPIWSVRLDFGDVLLATGGPLRLQVWDQDSGRDDDLLGTCDQAPKSGSHEVRCNLNHGHLKFRYHARCLPHLGGGTCLDYVPQMLLGEPPGNRSGAVW
  
Inhibitor
Name:
BDBM50235178
Synonyms:
CHEMBL4099714
Type:
Small organic molecule
Emp. Form.:
C23H16F2N4O3S2
Mol. Mass.:
498.525
SMILES:
CN1Cc2cc(ccc2C1=O)-c1nc(cs1)-c1cncc(NS(=O)(=O)c2ccc(F)cc2F)c1
Structure:
Search PDB for entries with ligand similarity: