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Target
Dihydrofolate reductase
Ligand
BDBM22985
Substrate
n/a
Meas. Tech.
ChEMBL_1657484 (CHEMBL4006954)
IC50
31.3±n/a nM
Citation
 Patel, TS; Vanparia, SF; Patel, UH; Dixit, RB; Chudasama, CJ; Patel, BD; Dixit, BC Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition. Eur J Med Chem 129:251-265 (2017) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM22985
Synonyms:
Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chlorochin | Chloroquine | Chloroquine, 17 | med.21724, Compound 8 | {4-[(7-chloroquinolin-4-yl)amino]pentyl}diethylamine
Type:
Antimalarial
Emp. Form.:
C18H26ClN3
Mol. Mass.:
319.872
SMILES:
CCN(CC)CCCC(C)Nc1ccnc2cc(Cl)ccc12
Structure:
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