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Target
Dihydrofolate reductase
Ligand
BDBM50235583
Substrate
n/a
Meas. Tech.
ChEMBL_1657484 (CHEMBL4006954)
IC50
97.4±n/a nM
Citation
 Patel, TS; Vanparia, SF; Patel, UH; Dixit, RB; Chudasama, CJ; Patel, BD; Dixit, BC Novel 2,3-disubstituted quinazoline-4(3H)-one molecules derived from amino acid linked sulphonamide as a potent malarial antifolates for DHFR inhibition. Eur J Med Chem 129:251-265 (2017) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DHFR | DYR_BOVIN | Dihydrofolate reductase | Dihydrofolate reductase (DHFR)
Type:
Enzyme
Mol. Mass.:
21603.71
Organism:
Bos taurus (Cattle)
Description:
P00376
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPPLRNEFQYFQRMTTVSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPKGAHFLAKSLDDALELIEDPELTNKVDVVWIVGGSSVYKEAMNKPGHVRLFVTRIMQEFESDAFFPEIDFEKYKLLPEYPGVPLDVQEEKGIKYKFEVYEKNN
  
Inhibitor
Name:
BDBM50235583
Synonyms:
CHEMBL4100781
Type:
Small organic molecule
Emp. Form.:
C26H28N4O4S
Mol. Mass.:
492.59
SMILES:
COc1ccc(cc1)-n1c(nc2ccccc2c1=O)C(CC(C)C)NS(=O)(=O)c1ccc(N)cc1
Structure:
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