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TargetInosine triphosphate pyrophosphatase
LigandBDBM50236118
Substrate/Competitorn/a
Meas. Tech.ChEBML_1658779
IC50>100000±n/a nM
Citation Llona-Minguez, SHöglund, AWiita, EAlmlöf, IMateus, ACalderón-Montaño, JMCazares-Körner, CHoman, ELoseva, OBaranczewski, PJemth, ASHäggblad, MMartens, ULundgren, BArtursson, PLundbäck, TJenmalm Jensen, AWarpman Berglund, UScobie, MHelleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem60:2148-2154 (2017) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Inosine triphosphate pyrophosphatase
Name:Inosine triphosphate pyrophosphatase
Synonyms:3.6.1.9 | C20orf37 | ITPA | ITPase | Inosine triphosphatase | Inosine triphosphate pyrophosphatase | NTPase | Non-canonical purine NTP pyrophosphatase | Non-standard purine NTP pyrophosphatase | Nucleoside-triphosphate diphosphatase | Nucleoside-triphosphate pyrophosphatase | Putative oncogene protein hlc14-06-p
Type:PROTEIN
Mol. Mass.:21443.41
Organism:Homo sapiens (Human)
Description:ChEMBL_117393
Residue:194
Sequence:
MAASLVGKKIVFVTGNAKKLEEVVQILGDKFPCTLVAQKIDLPEYQGEPDEISIQKCQEA
VRQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLAGFEDKSAYALCTFAL
STGDPSQPVRLFRGRTSGRIVAPRGCQDFGWDPCFQPDGYEQTYAEMPKAEKNAVSHRFR
ALLELQEYFGSLAA
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  Blast E-value cutoff:
BDBM50236118
NameBDBM50236118
Synonyms:CHEMBL4065181
TypeSmall organic molecule
Emp. Form.C15H12N4O2S2
Mol. Mass.344.411
SMILESCOc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure
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n/a