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TargetADP-ribose pyrophosphatase, mitochondrial
LigandBDBM50236118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1658777
IC50>100000±n/a nM
Citation Llona-Minguez, SHöglund, AWiita, EAlmlöf, IMateus, ACalderón-Montaño, JMCazares-Körner, CHoman, ELoseva, OBaranczewski, PJemth, ASHäggblad, MMartens, ULundgren, BArtursson, PLundbäck, TJenmalm Jensen, AWarpman Berglund, UScobie, MHelleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem60:2148-2154 (2017) [PubMed]  Article
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ADP-ribose pyrophosphatase, mitochondrial
Name:ADP-ribose pyrophosphatase, mitochondrial
Synonyms:3.6.1.13 | ADP-ribose diphosphatase | ADP-ribose phosphohydrolase | ADP-ribose pyrophosphatase, mitochondrial | ADPR-PPase | Adenosine diphosphoribose pyrophosphatase | NUDT10 | NUDT9 | Nucleoside diphosphate-linked moiety X motif 9 | Nudix motif 9
Type:PROTEIN
Mol. Mass.:39132.57
Organism:Homo sapiens (Human)
Description:ChEMBL_117589
Residue:350
Sequence:
MAGRLLGKALAAVSLSLALASVTIRSSRCRGIQAFRNSFSSSWFHLNTNVMSGSNGSKEN
SHNKARTSPYPGSKVERSQVPNEKVGWLVEWQDYKPVEYTAVSVLAGPRWADPQISESNF
SPKFNEKDGHVERKSKNGLYEIENGRPRNPAGRTGLVGRGLLGRWGPNHAADPIITRWKR
DSSGNKIMHPVSGKHILQFVAIKRKDCGEWAIPGGMVDPGEKISATLKREFGEEALNSLQ
KTSAEKREIEEKLHKLFSQDHLVIYKGYVDDPRNTDNAWMETEAVNYHDETGEIMDNLML
EAGDDAGKVKWVDINDKLKLYASHSQFIKLVAEKRDAHWSEDSEADCHAL
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  Blast E-value cutoff:
BDBM50236118
NameBDBM50236118
Synonyms:CHEMBL4065181
TypeSmall organic molecule
Emp. Form.C15H12N4O2S2
Mol. Mass.344.411
SMILESCOc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1cccs1
Structure
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