Reaction Details Report a problem with these data
Target
dCTP pyrophosphatase 1
Ligand
BDBM38321
Substrate
n/a
Meas. Tech.
ChEMBL_1658761 (CHEMBL4008373)
IC50
19±n/a nM
Citation
Llona-Minguez, S; Höglund, A; Wiita, E; Almlöf, I; Mateus, A; Calderón-Montaño, JM; Cazares-Körner, C; Homan, E; Loseva, O; Baranczewski, P; Jemth, AS; Häggblad, M; Martens, U; Lundgren, B; Artursson, P; Lundbäck, T; Jenmalm Jensen, A; Warpman Berglund, U; Scobie, M; Helleday, T Identification of Triazolothiadiazoles as Potent Inhibitors of the dCTP Pyrophosphatase 1. J Med Chem 60:2148-2154 (2017) [PubMed] Article
More Info.:
Target
Name:
dCTP pyrophosphatase 1
Synonyms:
DCTP1_HUMAN | DCTPP1 | Deoxycytidine-triphosphatase 1 | XTP3TPA | dCTP pyrophosphatase 1 | dCTP pyrophosphatase 1 (DCTPP1)
Type:
Protein
Mol. Mass.:
18673.58
Organism:
Homo sapiens (Human)
Description:
Q9H773
Residue:
170
Sequence:
MSVAGGEIRGDTGGEDTAAPGRFSFSPEPTLEDIRRLHAEFAAERDWEQFHQPRNLLLALVGEVGELAELFQWKTDGEPGPQGWSPRERAALQEELSDVLIYLVALAARCRVDLPLAVLSKMDINRRRYPAHLARSSSRKYTELPHGAISEDQAVGPADIPCDSTGQTST
Inhibitor
Name:
BDBM38321
Synonyms:
6-(3,4-dimethoxyphenyl)-3-(2-furanyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-(2-furyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3,4-dimethoxyphenyl)-3-(furan-2-yl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | MLS000037114 | SMR000042111 | cid_661498
Type:
Small organic molecule
Emp. Form.:
C15H12N4O3S
Mol. Mass.:
328.346
SMILES:
COc1ccc(cc1OC)-c1nn2c(nnc2s1)-c1ccco1