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Target
Transmembrane protease serine 6
Ligand
BDBM50236931
Substrate
n/a
Meas. Tech.
ChEMBL_1659751 (CHEMBL4009363)
Ki
2.6±n/a nM
Citation
 St-Georges, C; Désilets, A; Béliveau, F; Ghinet, M; Dion, SP; Colombo, É; Boudreault, PL; Najmanovich, RJ; Leduc, R; Marsault, É Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem 129:110-123 (2017) [PubMed]  Article 
Target
Name:
Transmembrane protease serine 6
Synonyms:
Matriptase-2 | TMPRSS6 | TMPS6_HUMAN
Type:
PROTEIN
Mol. Mass.:
90001.12
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1442547
Residue:
811
Sequence:
MLLLFHSKRMPVAEAPQVAGGQGDGGDGEEAEPEGMFKACEDSKRKARGYLRLVPLFVLLALLVLASAGVLLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQKMLKELITSTRLGTYYNSSSVYSFGEGPLTCFFWFILQIPEHRRLMLSPEVVQALLVEELLSTVNSSAAVPYRAEYEVDPEGLVILEASVKDIAALNSTLGCYRYSYVGQGQVLRLKGPDHLASSCLWHLQGPKDLMLKLRLEWTLAECRDRLAMYDVAGPLEKRLITSVYGCSRQEPVVEVLASGAIMAVVWKKGLHSYYDPFVLSVQPVVFQACEVNLTLDNRLDSQGVLSTPYFPSYYSPQTHCSWHLTVPSLDYGLALWFDAYALRRQKYDLPCTQGQWTIQNRRLCGLRILQPYAERIPVVATAGITINFTSQISLTGPGVRVHYGLYNQSDPCPGEFLCSVNGLCVPACDGVKDCPNGLDERNCVCRATFQCKEDSTCISLPKVCDGQPDCLNGSDEEQCQEGVPCGTFTFQCEDRSCVKKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMASTVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCSEVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWIQQVVT
  
Inhibitor
Name:
BDBM50236931
Synonyms:
CHEMBL4104560
Type:
Small organic molecule
Emp. Form.:
C38H47N7O4S
Mol. Mass.:
697.889
SMILES:
CC[C@@H](C)[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CCc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1 |r|
Structure:
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