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Target
Potassium voltage-gated channel subfamily A member 1/2
Ligand
BDBM50237157
Substrate
n/a
Meas. Tech.
ChEMBL_1659949 (CHEMBL4009561)
IC50
>100000±n/a nM
Citation
 Al-Sabi, A; Daly, D; Hoefer, P; Kinsella, GK; Metais, C; Pickering, M; Herron, C; Kaza, SK; Nolan, K; Dolly, JO A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction. J Med Chem 60:2245-2256 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 1/2
Synonyms:
Potassium voltage-gated channel subfamily A member 1/2 (Kv1.1/Kv1.2)
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1659948
Components:
This complex has 2 components.
Component 1
Name:
Potassium voltage-gated channel subfamily A member 1
Synonyms:
KCNA1_RAT | Kcna1 | Potassium voltage-gated channel subfamily A member 1 | RBKI | RCK1 | Voltage-gated potassium channel subunit Kv1.1
Type:
PROTEIN
Mol. Mass.:
56364.13
Organism:
Rattus norvegicus
Description:
ChEMBL_117743
Residue:
495
Sequence:
MTVMSGENADEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTATDQNCVNKSKLLTDV
  
Component 2
Name:
Potassium voltage-gated channel subfamily A member 2
Synonyms:
KCNA2_RAT | Kcna2 | Potassium voltage-gated channel subfamily A member 2 | RAK | RBK2 | RCK5 | Voltage-gated potassium channel subunit Kv1.2
Type:
PROTEIN
Mol. Mass.:
56679.97
Organism:
Rattus norvegicus
Description:
ChEMBL_117743
Residue:
499
Sequence:
MTVATGDPVDEAAALPGHPQDTYDPEADHECCERVVINISGLRFETQLKTLAQFPETLLGDPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDIFSEEIRFYELGEEAMEMFREDEGYIKEEERPLPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCLETLPIFRDENEDMHGGGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFFACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADERDSQFPSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQYLQVTSCPKIPSSPDLKKSRSASTISKSDYMEIQEGVNNSNEDFREENLKTANCTLANTNYVNITKMLTDV
  
Inhibitor
Name:
BDBM50237157
Synonyms:
CHEMBL4079366
Type:
Small organic molecule
Emp. Form.:
C29H36Cl2N6O2
Mol. Mass.:
571.541
SMILES:
Cl.Cl.Cc1ccc(cc1)C(c1ccc([nH]1)C(=O)NCCN)(c1ccc([nH]1)C(=O)NCCN)c1ccc(C)cc1
Structure:
Search PDB for entries with ligand similarity: