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Target
Potassium voltage-gated channel subfamily A member 1
Ligand
BDBM50101817
Substrate
n/a
Meas. Tech.
ChEMBL_1659962 (CHEMBL4009574)
IC50
96000±n/a nM
Citation
 Al-Sabi, A; Daly, D; Hoefer, P; Kinsella, GK; Metais, C; Pickering, M; Herron, C; Kaza, SK; Nolan, K; Dolly, JO A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves That Improves Their Impaired Axonal Conduction. J Med Chem 60:2245-2256 (2017) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 1
Synonyms:
KCNA1 | KCNA1_HUMAN | Potassium (voltage dependent) | Potassium voltage-gated channel subfamily A member 1 | Voltage-gated potassium channel | Voltage-gated potassium channel subfamily A member 1/beta-1 | Voltage-gated potassium channel subunit Kv1.1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
56451.30
Organism:
Homo sapiens (Human)
Description:
Potassium (voltage dependent) 0 0::Q09470
Residue:
495
Sequence:
MTVMSGENVDEASAAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTMSKSEYMEIEEDMNNSIAHYRQVNIRTANCTTANQNCVNKSKLLTDV
  
Inhibitor
Name:
BDBM50101817
Synonyms:
Adalat | Adalat Cc | Afeditab Cr | BAY-A-1040 | CHEBI:7565 | Nifedipine | Procardia | Procardia Xl
Type:
Small organic molecule
Emp. Form.:
C17H18N2O6
Mol. Mass.:
346.3346
SMILES:
COC(=O)C1=C(C)NC(C)=C(C1c1ccccc1[N+]([O-])=O)C(=O)OC |c:4,9|
Structure:
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