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Target
m7GpppX diphosphatase
Ligand
BDBM50237217
Substrate
n/a
Meas. Tech.
ChEMBL_1660723 (CHEMBL4010335)
IC50
1.0±n/a nM
Citation
 Gopalsamy, A; Narayanan, A; Liu, S; Parikh, MD; Kyne, RE; Fadeyi, O; Tones, MA; Cherry, JJ; Nabhan, JF; LaRosa, G; Petersen, DN; Menard, C; Foley, TL; Noell, S; Ren, Y; Loria, PM; Maglich-Goodwin, J; Rong, H; Jones, LH Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA). J Med Chem 60:3094-3108 (2017) [PubMed]  Article 
Target
Name:
m7GpppX diphosphatase
Synonyms:
DCPS | DCPS_HUMAN | DCS1 | HINT5 | Scavenger mRNA-decapping enzyme (DcpS)
Type:
Enzyme
Mol. Mass.:
38606.80
Organism:
Homo sapiens (Human)
Description:
Q96C86
Residue:
337
Sequence:
MADAAPQLGKRKRELDVEEAHAASTEEKEAGVGNGTCAPVRLPFSGFRLQKVLRESARDKIIFLHGKVNEASGDGDGEDAVVILEKTPFQVEQVAQLLTGSPELQLQFSNDIYSTYHLFPPRQLNDVKTTVVYPATEKHLQKYLRQDLRLIRETGDDYRNITLPHLESQSLSIQWVYNILDKKAEADRIVFENPDPSDGFVLIPDLKWNQQQLDDLYLIAICHRRGIRSLRDLTPEHLPLLRNILHQGQEAILQRYRMKGDHLRVYLHYLPSYYHLHVHFTALGFEAPGSGVERAHLLAEVIENLECDPRHYQQRTLTFALRADDPLLKLLQEAQQS
  
Inhibitor
Name:
BDBM50237217
Synonyms:
CHEMBL342595
Type:
Small organic molecule
Emp. Form.:
C15H14N4O
Mol. Mass.:
266.2979
SMILES:
Nc1nc(N)c2c(OCc3ccccc3)cccc2n1
Structure:
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