Target
Tyrosine-protein kinase SYK
Ligand
BDBM50482
Substrate
n/a
Meas. Tech.
ChEMBL_1660848 (CHEMBL4010460)
IC50
120±n/a nM
Citation
 Huang, YZhang, YFan, KDong, GLi, BZhang, WLi, JSheng, C Discovery of new Syk inhibitors through structure-based virtual screening. Bioorg Med Chem Lett 27:1776-1779 (2017) [PubMed]  Article 
Target
Name:
Tyrosine-protein kinase SYK
Synonyms:
KSYK_HUMAN | SYK | Spleen Tyrosine Kinase | Spleen tyrosine kinase (SYK) | Tyrosine-protein kinase SYK (Syk)
Type:
Enzyme
Mol. Mass.:
72079.99
Organism:
Homo sapiens (Human)
Description:
P43405
Residue:
635
Sequence:
MASSGMADSANHLPFFFGNITREEAEDYLVQGGMSDGLYLLRQSRNYLGGFALSVAHGRKAHHYTIERELNGTYAIAGGRTHASPADLCHYHSQESDGLVCLLKKPFNRPQGVQPKTGPFEDLKENLIREYVKQTWNLQGQALEQAIISQKPQLEKLIATTAHEKMPWFHGKISREESEQIVLIGSKTNGKFLIRARDNNGSYALCLLHEGKVLHYRIDKDKTGKLSIPEGKKFDTLWQLVEHYSYKADGLLRVLTVPCQKIGTQGNVNFGGRPQLPGSHPATWSAGGIISRIKSYSFPKPGHRKSSPAQGNRQESTVSFNPYEPELAPWAADKGPQREALPMDTEVYESPYADPEEIRPKEVYLDRKLLTLEDKELGSGNFGTVKKGYYQMKKVVKTVAVKILKNEANDPALKDELLAEANVMQQLDNPYIVRMIGICEAESWMLVMEMAELGPLNKYLQQNRHVKDKNIIELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKISDFGLSKALRADENYYKAQTHGKWPVKWYAPECINYYKFSSKSDVWSFGVLMWEAFSYGQKPYRGMKGSEVTAMLEKGERMGCPAGCPREMYDLMNLCWTYDVENRPGFAAVELRLRNYYYDVVN
  
Inhibitor
Name:
BDBM50482
Synonyms:
(5Z)-5-(3-bromo-4,5-dihydroxy-benzylidene)-2-(p-tolyl)-2-thiazolin-4-one | (5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one | (5Z)-5-[(3-bromo-4,5-dihydroxyphenyl)methylidene]-2-(4-methylphenyl)-4-thiazolone | (5Z)-5-[[3-bromanyl-4,5-bis(oxidanyl)phenyl]methylidene]-2-(4-methylphenyl)-1,3-thiazol-4-one | 5-(3-bromo-4,5-dihydroxybenzylidene)-2-(4-methylphenyl)-1,3-thiazol-4(5H)-one | MLS000676730 | SMR000298379 | cid_5730111
Type:
Small organic molecule
Emp. Form.:
C17H12BrNO3S
Mol. Mass.:
390.251
SMILES:
Cc1ccc(cc1)C1=NC(=O)\C(S1)=C\c1cc(O)c(O)c(Br)c1 |t:8|
Structure:
Search PDB for entries with ligand similarity: