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Reaction Details
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TargetAcid ceramidase
LigandBDBM50238565
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1663372
IC50 9.9±n/a nM
Citation Ortega, JAArencibia, JMLa Sala, GBorgogno, MBauer, IBono, LBraccia, CArmirotti, AGirotto, SGanesan, ADe Vivo, M Pharmacophore Identification and Scaffold Exploration to Discover Novel, Potent, and Chemically Stable Inhibitors of Acid Ceramidase in Melanoma Cells. J Med Chem60:5800-5815 (2017) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Acid ceramidase
Name:Acid ceramidase
Synonyms:Acid ceramidase
Type:Enzyme
Mol. Mass.:44662.65
Organism:Homo sapiens (Human)
Description:Q13510
Residue:395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYK
RWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIA
AVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITE
QLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWI
LGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKE
SLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLST
KPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50238565
NameBDBM50238565
Synonyms:CHEMBL4095461
TypeSmall organic molecule
Emp. Form.C14H19N3O
Mol. Mass.245.3202
SMILESCCCCCCNC(=O)n1ncc2ccccc12
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a